Hydrochloric Acid → HCID 90016025, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-ethyl 2-(2-(5-bromo-2-fluorophenyl)-2-(2,4-dimethoxybenzylamino) propylthio)-2-methylpropanoate (3 g, 5.68 mmol, Eq: 1.00) in ethanol (35.7 ml) was added 3 N NaOH (3.78 ml, 11.4 mmol, Eq: 2.0). The reaction mixture was stirred at 70° C. for 2 hours. 1 N HCl (11.4 ml, 11.4 mmol, Eq: 2.0) was added to the reaction mixture at 23° C. (pH=5-6) and evaporated. The residue was triturated with dichloromethane/methanol 9:1, solid Na2SO4 was added. The mixture was filtered off. The filtrate was evaporated to dryness to give the crude (R)-2-(2-(5-bromo-2-fluorophenyl)-2-(2,4-dimethoxybenzylamino)propylthio)-2-methylpropanoic acid (2.6 g, 5.2 mmol, 91.5% yield) as an off-white foam which was used without further purification. MS (ISP): m/z=500.0 [M+H]+ and 502.3 [M+2+H]+.

Provenance & Evidence