HRID920189

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57475871

未命名化合物

结构：C[C@@]1(c2cc(N)ccc2F)CS(=O)(=O)CC(N)=N1

HCID90067101

未命名化合物

PRODUCTS

生成物

结构：C[C@@]1(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CS(=O)(=O)CC(N)=N1

HCID72547962

未命名化合物

收率 52.1%

PROCEDURE

实验过程

Prepared from 5-(difluoromethoxy)picolinic acid (69.7 mg, 369 μmol, Eq: 1.00) and (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-1,1-dioxo-1,2,5,6-tetrahydro-1λ6-[1,4]thiazin-3-ylamine (100 mg, 369 μmol, Eq: 1.00) as described for example 2 (method b) to give the title compound (85 mg, 192 μmol, 52.1% yield) as a white foam. MS (ISP): m/z=443.4 [(M+H)].