反应详情

Prepared from 5-chloropicolinic acid (60.8 mg, 386 μmol, Eq: 1.1) and (R)-5-(5-amino-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1,2,5,6-tetrahydro-1λ6-[1,4]thiazin-3-ylamine (105 mg, 351 μmol, Eq: 1.00) as described for example 2 (method b) to give the title compound (150 mg, 342 μmol, 97.4% yield) as a white foam. MS (ISP): m/z=439.3 [(M+H)+] and 441.2 [(M+2+H)+].