反应详情

Prepared from commercially available 5-methoxypyrazine-2-carboxylic acid (CAS-no. 40155-42-8) (43.2 mg, 281 μmol, Eq: 1.2) and (R)-5-(5-amino-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1,2,5,6-tetrahydro-1λ6-[1,4]thiazin-3-ylamine (70 mg, 234 μmol, Eq: 1.00) as described for example 2 (method b) to give the title compound (67 mg, 154 μmol, 65.8% yield) as a white foam. MS (ISP): m/z=436.5 [(M+H)+].