5-Difluoromethympyrazine-2-carboxylic acid → HCID 72548197, compound

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Reaction Steps

Prepared from commercially available 5-(difluoromethyl)pyrazine-2-carboxylic acid (CAS-no. 1174321-06-2) (48.9 mg, 281 μmol, Eq: 1.2) and (R)-5-(5-amino-2-fluoro-phenyl)-2,2,5-trimethyl-1,1-dioxo-1,2,5,6-tetrahydro-1λ6-[1,4]thiazin-3-ylamine (70 mg, 234 μmol, Eq: 1.00) as described for example 2 (method b) to give the title compound (51 mg, 112 μmol, 47.9% yield) as a light yellow foam. MS (ISP): m/z=456.5 [(M+H)+].

Provenance & Evidence