5-Chloro-2-picolinic acid → HCID 89419854, compound

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Reaction Steps

Prepared from 5-chloropicolinic acid (48.6 mg, 308 μmol, Eq: 1.2) and (R)-7-(5-amino-2-fluoro-phenyl)-7-methyl-5,5-dioxo-5λ6-thia-8-aza-spiro[3.5]non-8-en-9-ylamine (80 mg, 257 mmol, Eq: 1.00) as described for example 2 (method b) to give the title compound (70 mg, 155 mmol, 60.4% yield) as a light yellow foam. MS (ISP): m/z=451.4 [(M+H)+] and 453.2 [(M+2+H)+].

Provenance & Evidence