5-Cyanopyridine-2-carboxylic acid → HCID 71532014, compound

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Reaction Steps

Prepared from 5-cyanopicolinic acid (33.1 mg, 224 μmol, Eq: 1.2) and (R)-7-(5-amino-2-fluoro-phenyl)-7-methyl-5,5-dioxo-5λ6-thia-8-aza-spiro[3.5]non-8-en-9-ylamine (58 mg, 186 mmol, Eq: 1.00) as described for example 2 (method b) to give the title compound (39 mg, 88.3 mmol, 47.4% yield) as a light yellow foam. MS (ISP): m/z=442.4 [(M+H)+].

Provenance & Evidence