Methanol → 4-Hydroxy-3-isopropylpiperidine

HRID 92021Notes

Reaction equation

HRID 92021 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH:15]([CH3:16])[CH3:17])[CH:11]([OH:14])[CH2:12][CH2:13]1.[CH3:18][OH:19].[H:20][H:21].[OH-:22].[OH-:24].[Pd+2:23]>>[NH:8]1[CH2:9][CH:10]([CH:15]([CH3:16])[CH3:17])[CH:11]([OH:14])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 230037111-Benzyl-4-hydroxy-3-isopropylpiperidineHCID 178418361HCID 178418361, compound

Product 1

HCID 230036734-Hydroxy-3-isopropylpiperidine

Sources & evidence

ORD record
ord-9be12061dfa041d4ba81153b02d45964
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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