Diisobutylaluminumhydride → HCID 89533741, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Formula 8-2 (0.080 g, 0.297 mmol) was dissolved in 1.5 mL of THF and the solution was cooled to 0° C., then treated with 1.5 mL di-isobutyl aluminum hydride (DIBAl—H 1.5 mmol). The reaction mixture was stirred for 1 hour maintaining the temperature at 0° C., then quenched with 2N HCl and stirred at RT for 30 minutes additional. The reaction mixture was extracted into EtOAc three times. The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo to yield 8-3 ([2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-8-yl]methanol).

Provenance & Evidence