Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 89524977 | HCID 89524977 | — |
| Product | HCID 89524828 | HCID 89524828 | — |
Reaction Steps
A 20 mL microwave vial was charged with 3-chloroisoquinoline-5-carboxylic acid (1 g, 4.82 mmol) in 5 mL of MeOH and then was added with thionyl chloride (0.703 mL, 9.63 mmol). Stirred at 65° C. overnight and then concentrated in vacuo. Purified by silica gel chromatography (0-50% EtOAc in hexane) yielded Methyl 3-chloroisoquinoline-5-carboxylate (26-1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273040B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-e3ee58d77d764441b86274cae46a41b2 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
