HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920253Generated: October 30, 2026
Methanol → Methyl 3-chloroisoquinoline-8-carboxylate
https://huagongshe.com/reaction/920253
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloroisoquinoline-8-carboxylic acid | HCID 89524883 | — |
| Product | Methyl 3-chloroisoquinoline-8-carboxylate | HCID 89524931 | — |
Reaction Steps
A 20 mL microwave vial was charged with 3-chloroisoquinoline-8-carboxylic acid (1 g, 4.82 mmol) in 5 mL of MeOH and then was added with thionyl chloride (0.703 mL, 9.63 mmol). Stirred at 65° C. overnight and then concentrated in vacuo. Purified by silica gel chromatography (0-50% EtOAc in hexane) yielded Methyl 3-chloroisoquinoline-8-carboxylate (27-1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273040B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-78db16cbef6245fd9c63740650ea06cc |
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| Source note | uspto-grants-2016_03 |
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