Trifluoroacetic acid → HCID 89526084, compound

Participants

Reaction Steps

A solution of the compound of Formula 37-3 was prepared by dissolving the compound of Formula 37-2 (crude from previous step) in dichloromethane (1 mL), and treating the resulting solution with trifluoroacetic acid (0.2 mL). After stirring for 30 minutes at RT, the solution was concentrated and purified by reverse phase HPLC (20-100% MeCN in water with 0.1% TFA, C18 column) to yield the compound of Formula 37-3 as the a white solid. 1H NMR δ (ppm)(Methanol-d): 8.20 (s, 1H); 7.74 (m, 1H); 7.51 (m, 2H); 7.42-7.42 (m, 3H); 7.12 (m, 1H); 5.60 (m, 1H); 4.65-4.37 (m, 2H); 3.01-2.65 (m, 2H). HRMS C18H15F2N404S2 [M+H] calc 453.0425, obs 453.0497.

Provenance & Evidence