1-Phenylethanol → HCID 89524851, compound

Participants

Reaction Steps

Into a solution of 6-nitrobenzo[d]oxazol-2(3H)-one (40-1, 5 g, 27.8 mmol) in THF (139 ml) was added α-methylbenzylalcohol (3.7 g, 30.5 mmol), polymer-bound triphenylphosphine (27.7 g, 83 mmol), and DIAD (11.2 g, 55.5 mmol). The reaction was shaken for 1 h at rt, filtered, and concentrated to yield 6-nitro-3-(1-phenylethyl)benzo[d]oxazol-2(3H)-one (7.89 g, 27.8 mmol) which was taken on to the next step without further purification. LRMS C15H14N202 [M−79] calc 205.1, obs 205.4.

Provenance & Evidence