HCID 89524851, compound → HCID 89524847, compound

Participants

Reaction Steps

Into a solution of 6-nitro-3-(1-phenylethyl)benzo[d]oxazol-2(3H)-one (40-2, 7.89 g, 27.8 mmol) in EtOH (139 ml) was added Pd/C (295 mg, 2.78 mmol). The reaction was stirred under 1 atm of H2 for 2 h, filtered through celite, concentrated and purified using a 50 g SCX column (eluting with 2 N NH3 in MeOH) to yield 6-amino-3-(1-phenylethyl)benzo[d]oxazol-2(3H)-one (4.4 g, 17.3 mmol). LRMS C15H14N202 [M+H] calc 255.1, obs 255.4.

Provenance & Evidence