HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 67774932, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)pyridine | HCID 92342 | — |
| Reactant | 2-Hydroxy-5-iodo-benzonitrile | HCID 7023040 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67774932 | HCID 67774932 | 93.8% |
Reaction Steps
K2CO3 (91.0 g, 0.656 mol) was added to a solution of 2-hydroxy-5-iodo-benzonitrile (80.0 g, 0.328 mol) and 2-chloro-5-tri-fluoromethyl-pyridine (60.0 g, 0.328 mol) in DMF (500 ml) was added. The reaction mixture was refluxed overnight, filtered and concentrated. Purification via FC (PE/EtOAc=10/1) afforded the title product as a white solid (120 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273054B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-475a2d20b7844dfeafe0985faedc1380 |
| Source note | uspto-grants-2016_03 |