反应详情

温度

120 °C

To a solution of 4-(4-Chloro-3-(trifluoromethyl)phenoxy)benzaldehyde (13 g, 43.2 mmol) and ammonium acetate (1.67 g, 21.62 mmol) in HOAc (40 mL), was added nitromethane (6.99 mL, 130 mmol). The reaction mixture was stirred at 120° C. for 5 h, and concentrated. The residue was dissolved in DCM (150 mL), washed with sat. aqueous NaHCO3 (100 mL×2), brine and then, dried over anhydrous Na2SO4 and concentrated to afford the title compound as a brown solid (14.3 g, 63% yield).

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in DCM (150 mL)
3. washwashed with sat. aqueous NaHCO3 (100 mL×2), brine
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated