Potassium Hydroxide → HCID 71236792, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of diethyl 2-(6-(3,4-difluorophenoxy)pyridin-3-yl)malonate (25 g, 34.9 mmol) in ethanol (250 mL) was added potassium hydroxide (19.58 g, 349 mmol). The reaction mixture was stirred at 80° C. for 1 hr. and then the reaction mixture was concentrated under the reduced pressure. To the residue was added 10% HCl to adjust the solution to approximately pH 7. Then, the solution was extracted with EtOAc (300 mL), and the organic layer was separated, and dried over Na2SO4, and then concentrated under reduced pressure to give 2-(6-(3,4-difluorophenoxy)pyridin-3-yl)acetic acid (10 g, 98%).

Provenance & Evidence