Ethanol → HCID 71236733, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(6-(3,4-difluorophenoxy)pyridin-3-yl)acetic acid (10 g, 37.7 mmol) in ethanol (100 mL) was added sulfuric acid (20 ml, 375 mmol) in ethanol (100 mL). The reaction mixture was stirred at 80° C. for 3 hr. and then the reaction mixture was made alkali with Na2CO3, and then extracted with CH2Cl2. The organic layer was separated and dried over Na2SO4, and then concentrated under reduced pressure to provide ethyl 2-(6-(3,4-difluorophenoxy)pyridin-3-yl)acetate (10 g, 78%).

Provenance & Evidence