Water → HCID 71236580, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(4-chloro-3-(trifluoromethyl)phenoxy)-2-nitropyridine (8 g, 25.1 mmol) in ethanol (100 mL) was added tin (II) chloride dihydrate (56.7 g, 251 mmol). The reaction mixture was stirred at 80° C. for 2 hr. and poured into 500 mL of H2O and adjusted to basic with 10% NaHCO3. Then, the reaction mixture was extracted with 500 mL of EtOAc. The organic layer was separated, and then dried over Na2SO4, and concentrated under reduced pressure to give 5-(4-chloro-3-(trifluoromethyl)-phenoxy)pyridin-2-amine (6 g, 72.9%).

Provenance & Evidence