Potassium Hydroxide → HCID 71236646, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of diethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)malonate (6 g, 5.42 mmol) in ethanol (60 mL) was added potassium hydroxide (3.04 g, 54.2 mmol). The reaction mixture was stirred at 80° C. for 1 hr., and then concentrated under reduced pressure. The reaction mixture was adjusted to pH 7 with 10% aqueous HCl solution. The reaction mixture was extracted with 100 mL of EtOAc, and the organic layer was separated, dried over Na2SO4, and then concentrated under reduced pressure to provide 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)acetic acid (3 g, 100%).

Provenance & Evidence