Ethanol → HCID 71236655, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)acetic acid (3 g, 5.61 mmol) in ethanol (30 mL) was added sulfuric acid (8 mL, 150 mmol) in ethanol (30 mL). The reaction mixture was stirred at 80° C. for 2 hr. Then 30 mL of 25% aqueous NH4OH solution and 50 mL CH2Cl2 were added to the reaction mixture. The organic layer was separated and dried over Na2SO4, and concentrated under reduced pressure to provide ethyl 2-(5-(4-chloro-3-(trifluoromethyl)phenoxy)pyridin-2-yl)acetate (2 g, 79%).

Provenance & Evidence