HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Chloro-4-(4-ethynylphenoxy)-2-(trifluoromethyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (4-Chloro-3-(trifluoromethyl)phenoxy)benzaldehyde | HCID 86676377 | — |
| Reactant | (1E)-1-diazo-1-dimethoxyphosphorylpropan-2-one | HCID 136023029 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Chloro-4-(4-ethynylphenoxy)-2-(trifluoromethyl)benzene | HCID 86676376 | — |
Reaction Steps
To a solution of (4-chloro-3-(trifluoromethyl)phenoxy)benzaldehyde (1.82 g, 6.0 mmol) and dimethyl(1-diazo-2-oxopropyl)phosphonate (2.3 g, 12.1 mmol) in methanol (30 mL), was added potassium carbonate (4.18 g, 30.3 mmol), and stirred for 1 h at rt. The reaction mixture was concentrated and the residue was purified by FC (PE/EtOAc 20:1) to afford the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273054B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4a6f68f41378454a9ae29810213863a2 |
| Source note | uspto-grants-2016_03 |