3-Fluoro-4-(trifluoromethyl)phenol → 3,5-Difluoro-4-(3-fluoro-4-(trifluoromethyl)phenoxy)benzaldehyde

HRID 920336Notes

Reaction equation

HRID 920336 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1F)[CH:5]=[O:6].[F:12][C:13]1[CH:14]=[C:15]([OH:23])[CH:16]=[CH:17][C:18]=1[C:19]([F:22])([F:21])[F:20]>>[F:11][C:8]1[CH:7]=[C:4]([CH:3]=[C:2]([F:1])[C:9]=1[O:23][C:15]1[CH:16]=[CH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[C:13]([F:12])[CH:14]=1)[CH:5]=[O:6]

Participants

3

Reactant 2

HCID 27748003-Fluoro-4-(trifluoromethyl)phenolHCID 27769543,4,5-Trifluorobenzaldehyde

Product 1

HCID 866763823,5-Difluoro-4-(3-fluoro-4-(trifluoromethyl)phenoxy)benzaldehyde

Procedure

The title compound was prepared by a procedure similar to that described for D4 starting from 3,4,5-trifluorobenzaldehyde and 3-fluoro-4-(trifluoromethyl)phenol.

Sources & evidence

ORD record
ord-5c53dec01ec14077aa941a17cefb88a8
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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