4-Chloro-3-(trifluoromethyl)phenol → Benzonitrile, 2-[4-chloro-3-(trifluoromethyl)phenoxy]-5-formyl-

HRID 920352Notes

Reaction equation

HRID 920352 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21]>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:2]2[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[CH:6][C:3]=2[C:4]#[N:5])=[CH:15][C:14]=1[C:20]([F:21])([F:22])[F:23]

Participants

3

Reactant 2

HCID 805204-Chloro-3-(trifluoromethyl)phenolHCID 27695822-Fluoro-5-formylbenzonitrile

Product 1

HCID 86666201Benzonitrile, 2-[4-chloro-3-(trifluoromethyl)phenoxy]-5-formyl-

Procedure

The title compound was prepared by a procedure similar to that described for D4 starting from 2-fluoro-5-formylbenzonitrile and 4-chloro-3-(trifluoromethyl)phenol.

Sources & evidence

ORD record
ord-b8510731a26447d88a049a0c3daf9a19
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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