Ammonium formate → Ethyl 6-(3,4-difluoro phenoxy)-5-fluoronicotinate

https://huagongshe.com/reaction/920355

Participants

Role	Name	HCID	Charge
Reactant	Ammonium formate	HCID 2723923	—
Reactant	Ethyl 2-chloro-6-(3,4-difluorophenoxy)-5-fluoronicotinate	HCID 86676389	—
Catalyst	Palladium	HCID 23938	—
Solvent	Methanol	HCID 887	—
Product	Ethyl 6-(3,4-difluoro phenoxy)-5-fluoronicotinate	HCID 71236611	74.8%

Reaction Conditions

Temperature	65 °C

Reaction Steps

To a solution of ammonium formate (28.5 g, 452 mmol) and ethyl 2-chloro-6-(3,4-difluorophenoxy)-5-fluoronicotinate (30 g, 90 mmol) in methanol (300 mL) was added Pd/C (3 g, 2.82 mmol). The reaction mixture was stirred at 65° C. for 10 hr. and then filtered. The filtrate was concentrated under reduced pressure to get ethyl 6-(3,4-difluoro phenoxy)-5-fluoronicotinate (20 g, 48.4%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09273054B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-3feea6b5f36e407f8c5146b2e1f0957c
Source note	uspto-grants-2016_03