Trimethylsilyl cyanide → HCID 71236677, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (6-(3,4-difluorophenoxy)-5-fluoropyridin-3-yl)methyl methanesulfonate (8 g, 11.28 mmol) and tetrabutylammonium fluoride (5.90 g, 22.56 mmol) in acetonitrile (100 mL) was added trimethylsilyl cyanide (3.02 mL, 22.56 mmol). The reaction mixture was stirred at 80° C. for 2 hr., and then concentrated under reduced pressure. The crude product was purified bysilica gel chromatography eluting with Hex/EtOAc (5:1) to give get 2-(6-(3,4-difluorophenoxy)-5-fluoropyridin-3-yl)acetonitrile (3 g, 89%).

Provenance & Evidence