Ethanol → HCID 71236664, compound

Participants

Reaction Conditions

Reaction Steps

To 2-(6-(3,4-difluorophenoxy)-5-fluoropyridin-3-yl)acetonitrile (3 g, 9.99 mmol) and EtOH (30 ml, 514 mmol) was added 18 M sulfuric acid (10 ml, 180 mmol). The reaction mixture was stirred at 80° C. for 2 hr., and then was concentrated under reduced pressure. To the residue was added 50 mL of concentrated ammonia solution and 100 mL of CH2Cl2. The organic layer was separated and dried over Na2SO4, and then concentrated under reduced pressure to give ethyl 2-(6-(3,4-difluorophenoxy)-5-fluoropyridin-3-yl)acetate (3.1 g, 67.8%).

Provenance & Evidence