(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanol → 8-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920366Notes

Reaction equation

HRID 920366 reaction equation
Cl[C:2]1[CH:12]=[C:6]2[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:13])[N:3]=1.[F:14][C:15]1[CH:16]=[C:17]([CH:28]=[CH:29][C:30]=1[F:31])[O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][OH:26])=[CH:21][C:20]=1[F:27]>>[F:14][C:15]1[CH:16]=[C:17]([CH:28]=[CH:29][C:30]=1[F:31])[O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][O:26][C:2]2[CH:12]=[C:6]3[N:7]([CH3:11])[CH2:8][CH2:9][CH2:10][N:5]3[C:4](=[O:13])[N:3]=2)=[CH:21][C:20]=1[F:27]

Participants

3

Reactant 2

HCID 43554868(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712366618-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (4-(3,4-difluorophenoxy)-3-fluorophenyl)methanol.

Sources & evidence

ORD record
ord-bdfccdc45146452695bb80cd900fc10f
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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