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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920367Generated: October 25, 2026

(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol → 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

https://huagongshe.com/reaction/920367

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanolHCID 66825563—
Reactant8-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-oneHCID 71743471—
Product8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-oneHCID 71236625—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09273054B2
Source datasetuspto-grants-2016_03
ORD IDord-da00b3fb080246239d6634842721098b
Source noteuspto-grants-2016_03