HCID 71236687, compound → HCID 71236631, compound

HRID 920386Notes

Reaction equation

HRID 920386 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:8]=2[C:9]#[N:10])=[CH:4][CH:3]=1.Cl[C:20]1[CH:30]=[C:24]2[N:25]([CH3:29])[CH2:26][CH2:27][CH2:28][N:23]2[C:22](=[O:31])[N:21]=1>>[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:20]3[CH:30]=[C:24]4[N:25]([CH3:29])[CH2:26][CH2:27][CH2:28][N:23]4[C:22](=[O:31])[N:21]=3)=[CH:11][C:8]=2[C:9]#[N:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 71236687HCID 71236687, compoundHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 71236631HCID 71236631, compound

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from 2-(4-fluorophenoxy)-5-(hydroxymethyl)benzonitrile and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-f562baaad0cf4cfdb482453905762431
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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