2-(3,4-Dichlorophenyl)ethanol → 8-[2-(3,4-Dichloro-phenyl)-ethoxy]-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

HRID 920397Notes

Reaction equation

HRID 920397 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:13]1[CH:23]=[C:17]2[N:18]([CH3:22])[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:24])[N:14]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][O:11][C:13]2[CH:23]=[C:17]3[N:18]([CH3:22])[CH2:19][CH2:20][CH2:21][N:16]3[C:15](=[O:24])[N:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 2445582-(3,4-Dichlorophenyl)ethanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712365968-[2-(3,4-Dichloro-phenyl)-ethoxy]-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E11 starting from 2-(3,4-dichlorophenyl)ethanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-d16c2f12ceba4ce2812f7b764da4f1bc
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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