(3,5-Difluoro-4-(3-fluorophenoxy)phenyl)methanol → 8-((3,5-difluoro-4-(3-fluorophenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920426Notes

Reaction equation

HRID 920426 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:17][OH:18])[CH:5]=[C:6]([F:16])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1.Cl[C:20]1[CH:30]=[C:24]2[N:25]([CH3:29])[CH2:26][CH2:27][CH2:28][N:23]2[C:22](=[O:31])[N:21]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:16])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)[CH2:17][O:18][C:20]1[CH:30]=[C:24]2[N:25]([CH3:29])[CH2:26][CH2:27][CH2:28][N:23]2[C:22](=[O:31])[N:21]=1

Participants

3

Reactant 2

HCID 63077760(3,5-Difluoro-4-(3-fluorophenoxy)phenyl)methanolHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 712366098-((3,5-difluoro-4-(3-fluorophenoxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (3,5-difluoro-4-(3-fluorophenoxyl)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-e9006b575c3d462582612fe34e3c98fa
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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