HCID 71236582, compound → HCID 71240898, compound

HRID 920428Notes

Reaction equation

HRID 920428 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][C:7]=1[C:8]#[N:9].Cl[C:20]1[CH:30]=[C:24]2[N:25]([CH3:29])[CH2:26][CH2:27][CH2:28][N:23]2[C:22](=[O:31])[N:21]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:13]=[CH:12][C:11]([CH2:14][O:15][C:20]2[CH:30]=[C:24]3[N:25]([CH3:29])[CH2:26][CH2:27][CH2:28][N:23]3[C:22](=[O:31])[N:21]=2)=[CH:10][C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 71236582HCID 71236582, compoundHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 71240898HCID 71240898, compound

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from 2-(3-fluorophenoxy)-5-(hydroxymethyl)benzonitrile and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-7ea980b0d01e44888c74f3fb08cf1e3b
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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