8-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one → HCID 86676393, compound

HRID 920436Notes

Reaction equation

HRID 920436 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:21][OH:22])[CH:5]=[C:6]([F:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([C:16]([F:19])([F:18])[F:17])[CH:10]=1.Cl[C:24]1[CH:34]=[C:28]2[N:29]([CH3:33])[CH2:30][CH2:31][CH2:32][N:27]2[C:26](=[O:35])[N:25]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([C:16]([F:17])([F:18])[F:19])[CH:10]=1)[CH2:21][O:22][C:24]1[CH:34]=[C:28]2[N:29]([CH3:33])[CH2:30][CH2:31][CH2:32][N:27]2[C:26](=[O:35])[N:25]=1

Participants

3

Reactant 2

HCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-oneHCID 86676394HCID 86676394, compound

Product 1

HCID 86676393HCID 86676393, compound

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (3,5-difluoro-4-(4-fluoro-3-(trifluoromethyl)phenoxy)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-3867af660c74434a931f8010ea90b272
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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