HCID 71236602, compound → HCID 71236736, compound

HRID 920441Notes

Reaction equation

HRID 920441 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:12]=2[F:19])[CH:9]=1)[C:5]#[N:6].Cl[C:21]1[CH:31]=[C:25]2[N:26]([CH3:30])[CH2:27][CH2:28][CH2:29][N:24]2[C:23](=[O:32])[N:22]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:21]3[CH:31]=[C:25]4[N:26]([CH3:30])[CH2:27][CH2:28][CH2:29][N:24]4[C:23](=[O:32])[N:22]=3)=[CH:13][C:12]=2[F:19])[CH:9]=1)[C:5]#[N:6]

Participants

3

Reactant 2

HCID 71236602HCID 71236602, compoundHCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

Product 1

HCID 71236736HCID 71236736, compound

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from 3-fluoro-5-(2-fluoro-4-(hydroxymethyl)phenoxy)benzonitrile and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Sources & evidence

ORD record
ord-07a9c8e55a9c4ea1a3f8b488426f13d3
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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