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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920443Generated: October 30, 2026

2-(3-Fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl)ethanol → 8-(3-fluoro-4-(3-(trifluoromethyl)phenoxy)phenethoxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

https://huagongshe.com/reaction/920443

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl)ethanolHCID 71236561—
Reactant8-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-oneHCID 71743471—
Product8-(3-fluoro-4-(3-(trifluoromethyl)phenoxy)phenethoxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-oneHCID 71236723—

Reaction Steps

The title compound or its salt was prepared by a procedure similar to that described for E2 starting from 2-(3-fluoro-4-(3-(trifluoromethyl)phenoxy)phenyl)ethanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09273054B2
Source datasetuspto-grants-2016_03
ORD IDord-ddfd52c49a334849ab8046f0685c7300
Source noteuspto-grants-2016_03