2-(3,4-Dichlorophenyl)ethanol → 8-(3,4-dichlorophenethoxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920446Notes

Reaction equation

HRID 920446 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][OH:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:13]1[CH:29]=[C:17]2[N:18](C(OC(C)(C)C)=O)[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:30])[N:14]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[Cl:8])[CH2:9][CH2:10][O:11][C:13]1[CH:29]=[C:17]2[NH:18][CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:30])[N:14]=1

Participants

3

Reactant 2

HCID 2445582-(3,4-Dichlorophenyl)ethanolHCID 71743562Tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-A]pyrimidine-1-carboxylate

Product 1

HCID 712366848-(3,4-dichlorophenethoxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E111 starting from 2-(3,4-dichlorophenyl)ethanol and tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidine-1-carboxylate.

Sources & evidence

ORD record
ord-c34c0cf92ab949618cb23aa4b6f0eac0
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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