3,4,5-Trifluorobenzyl alcohol → HCID 71236622, compound

HRID 920447Notes

Reaction equation

HRID 920447 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][OH:11])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].Cl[C:13]1[CH:29]=[C:17]2[N:18](C(OC(C)(C)C)=O)[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:30])[N:14]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:9])[C:7]=1[F:8])[CH2:10][O:11][C:13]1[CH:29]=[C:17]2[NH:18][CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:30])[N:14]=1

Participants

3

Reactant 2

HCID 27770403,4,5-Trifluorobenzyl alcoholHCID 71743562HCID 71743562, compound

Product 1

HCID 71236622HCID 71236622, compound

Procedure

The title compound and/or its salt was prepared by a procedure similar to that described for E111 starting from (3,4,5-trifluorophenyl)methanol and tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidine-1-carboxylate.

Sources & evidence

ORD record
ord-b69facccafcb494aad140373d66149c6
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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