(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanol → 8-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920451Notes

Reaction equation

HRID 920451 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[F:18])[O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][C:7]=1[F:14].Cl[C:20]1[CH:36]=[C:24]2[N:25](C(OC(C)(C)C)=O)[CH2:26][CH2:27][CH2:28][N:23]2[C:22](=[O:37])[N:21]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[F:18])[O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][O:13][C:20]2[CH:36]=[C:24]3[NH:25][CH2:26][CH2:27][CH2:28][N:23]3[C:22](=[O:37])[N:21]=2)=[CH:8][C:7]=1[F:14]

Participants

3

Reactant 2

HCID 43554868(4-(3,4-Difluorophenoxy)-3-fluorophenyl)methanolHCID 71743562HCID 71743562, compound

Product 1

HCID 712367118-((4-(3,4-difluorophenoxy)-3-fluorobenzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E111 starting from (4-(3,4-difluorophenoxy)-3-fluorophenyl)methanol and tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidine-1-carboxylate.

Sources & evidence

ORD record
ord-f7bb97c10fe740a6a40e54aa712f2d64
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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