(3-Fluoro-4-(4-fluorophenoxy)phenyl)methanol → 8-((3-fluoro-4-(4-fluorophenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 920452Notes

Reaction equation

HRID 920452 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:16][OH:17])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.Cl[C:19]1[CH:35]=[C:23]2[N:24](C(OC(C)(C)C)=O)[CH2:25][CH2:26][CH2:27][N:22]2[C:21](=[O:36])[N:20]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)[CH2:16][O:17][C:19]1[CH:35]=[C:23]2[NH:24][CH2:25][CH2:26][CH2:27][N:22]2[C:21](=[O:36])[N:20]=1

Participants

3

Reactant 2

HCID 28946101(3-Fluoro-4-(4-fluorophenoxy)phenyl)methanolHCID 71743562Tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-A]pyrimidine-1-carboxylate

Product 1

HCID 712367098-((3-fluoro-4-(4-fluorophenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E111 starting from (3-fluoro-4-(4-fluorophenoxyl)phenyl)methanol and tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidine-1-carboxylate.

Sources & evidence

ORD record
ord-0936fde6573a447ea1a344beed9d68ba
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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