HCID 43554866, compound → HCID 71236589, compound

HRID 920453Notes

Reaction equation

HRID 920453 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][CH:7]=1.Cl[C:19]1[CH:35]=[C:23]2[N:24](C(OC(C)(C)C)=O)[CH2:25][CH2:26][CH2:27][N:22]2[C:21](=[O:36])[N:20]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:12][O:13][C:19]2[CH:35]=[C:23]3[NH:24][CH2:25][CH2:26][CH2:27][N:22]3[C:21](=[O:36])[N:20]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 43554866HCID 43554866, compoundHCID 71743562Tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-A]pyrimidine-1-carboxylate

Product 1

HCID 71236589HCID 71236589, compound

Procedure

The title compound or its salt was prepared by a procedure similar to that described for E111 starting from (4-(3,4-difluorophenoxy)phenyl)methanol and tert-butyl 8-chloro-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidine-1-carboxylate.

Sources & evidence

ORD record
ord-27d862c68f5847a98da1523178376f4f
Source dataset
uspto-grants-2016_03
Patent number
US09273054B2

Reaction notes

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