HRID920466

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86663212

未命名化合物

结构：CN1CCC(N2C(=O)c3cc4nc(-c5c(Cl)cc[nH]c5=O)[nH]c4cc3C2=O)CC1

HCID136200220

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(C1CCN(C)CC1)C3=O

HCID136340639

未命名化合物

PROCEDURE

实验过程

(S)-1-(2,3,5,6-Tetrafluorophenyl)propan-2-amine and 2-(4-chloro-2-oxo-1,2-dihydropyridin-3-yl)-6-(1-methylpiperidin-4-yl)imidazo[4,5-f]isoindole-5,7(1H,6H)-dione were submitted to general procedure A. The isolated solid was triturated with water once and MeOH four times to give the title compound as an off-white solid, which was used directly in the next step.

WORKUP

后处理

customThe isolated solid was triturated with water once

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-09548499165a4a36a8a8ba38230ada7f
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09273055B2
来源说明: uspto-grants-2016_03

反应 SMILES

[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH2:11][C@@H:12]([NH2:14])[CH3:13].Cl[C:16]1[CH:21]=[CH:20][NH:19][C:18](=[O:22])[C:17]=1[C:23]1[NH:43][C:26]2=[CH:27][C:28]3[C:29](=[O:42])[N:30]([CH:35]4[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]4)[C:31](=[O:34])[C:32]=3[CH:33]=[C:25]2[N:24]=1>>[CH3:41][N:38]1[CH2:39][CH2:40][CH:35]([N:30]2[C:29](=[O:42])[C:28]3[CH:27]=[C:26]4[NH:43][C:23]([C:17]5[C:18](=[O:22])[NH:19][CH:20]=[CH:21][C:16]=5[NH:14][C@@H:12]([CH3:13])[CH2:11][C:3]5[C:2]([F:1])=[C:7]([F:8])[CH:6]=[C:5]([F:9])[C:4]=5[F:10])=[N:24][C:25]4=[CH:33][C:32]=3[C:31]2=[O:34])[CH2:36][CH2:37]1