反应详情

To a solution of 4-(4-benzyl-morpholin-2-yl)-benzaldehyde (1.19 g; 4.23 mmol) in MeOH (25 mL) was added NaBH4 (0.16 g; 4.23 mmol), in small portions, at 0° C. After the addition was complete the mixture was allowed to warm to RT and stirred for one hour. Subsequently, the mixture was cooled to 0° C., water was added, and the MeOH evaporated in vacuo. To the aqueous solution was added a 5% aqueous NaHCO3 solution and EtOAc. The layers were separated and the organic layer was dried (Na2SO4), filtered and concentrated in vacuo to afford [4-(4-benzyl-morpholin-2-yl)-phenyl]-methanol (1.16 g) which was used as such.

1. customat 0° C
2. additionAfter the addition
3. temperatureSubsequently, the mixture was cooled to 0° C.
4. customthe MeOH evaporated in vacuo
5. additionTo the aqueous solution was added a 5% aqueous NaHCO3 solution and EtOAc
6. customThe layers were separated
7. dry with materialthe organic layer was dried (Na2SO4)
8. filtrationfiltered
9. concentrationconcentrated in vacuo