Potassium Phosphate, Tribasic → HCID 67032289, compound

Participants

Reaction Steps

To a degassed solution of potassium[2-(2,6-dichlorophenyl)ethyl]trifluoroborate (0.28 g; 1 mmol) and potassium phosphate tribasic (0.58 g; 2.7 mmol) in toluene (20 mL) and water (4 mL) was added 4-benzyl-6-(4-bromo-phenyl)-morpholine (0.30 g; 0.90 mmol), palladium(II) acetate (6.1 mg; 0.03 mmol), and 2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl (25.3 mg; 0.05 mmol). The resulting mixture was heated under reflux, overnight. After cooling to RT, the mixture was concentrated in vacuo and partitioned between EtOAc and 5% aqueous NaHCO3. The organic layer was dried (Na2SO4), filtered, and concentrated in vacuo. The residue was purified by column chromatography (SiO2, Et2O:hexanes 1:1) to afford 4-benzyl-2-{4-[2-(2,6-dichloro-phenyl)-ethyl]-phenyl}-morpholine (0.21 g).

Provenance & Evidence