Water → HCID 86669536, compound

HRID 920596Notes

Reaction equation

HRID 920596 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-:12].[K+].[Mn]([O-])(=O)(=O)=O.[K+].[OH2:20]>>[Cl:1][C:2]1[C:3]([C:4]([OH:6])=[O:5])=[CH:7][CH:8]=[C:9]([C:11]([OH:20])=[O:12])[N:10]=1

Participants

5

Reactant 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 1217242-Chloro-6-methylnicotinic acidHCID 516875Potassium Permanganate

Product 1

HCID 86669536HCID 86669536, compound

Procedure

To a mixture of compound 2-chloro-6-methyl-nicotinic acid (25 gram, 0.146 mol) and water (1.5 L) in a 3 liter flask equipped with a mechanic stirrer and a heating mantle, potassium hydroxide (28 g, 0.5 mol) was added, the mixture turned to be a clear solution. Potassium permanganate (70 g, 0.44 mol) was added in ten batches during 36 hrs, the temperature of the reaction mixture was kept in the range of 85-95° C. during the reaction process.

Workup

  1. customequipped with a mechanic stirrer
  2. customwas kept in the range of 85-95° C. during the reaction process

Sources & evidence

ORD record
ord-d87529631e454dc2bea16cc31ef95430
Source dataset
uspto-grants-2016_03
Patent number
US09273059B2

Reaction notes

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