HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → HCID 67125498, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | HCID 67125523 | HCID 67125523 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67125498 | HCID 67125498 | — |
Reaction Steps
7-Difluoromethoxy-2′,3′,5′,6′-tetrahydro-spiro[1,3-benzodioxole-2,4′-(4H)-thiopyran]-4-carboxylic acid (344 mg) was dissolved in dry DMF (3 mL). 4-Nitrophenol (226 mg) Ethyl-dimethylaminopropylcarbodiimide hydrochloride (312 mg) and N,N-Dimethyl-4-aminopyridine (198 mg) was added. After stirring at room temperature for 20 hours, aqueous work up with tert-Butyl methyl ether and chromatography of the organics in a gradient from 0 to 40% EtOAc in pentanes afforded the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273064B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-69c5ad80798140938b55321140caf01d |
| Source note | uspto-grants-2016_03 |