Hydrochloric Acid → HCID 118062621, compound

Participants

Reaction Steps

To a stirred solution of Intermediate 302B (0.6 g, 2.56 mmol) was added a conc. aq. solution of HCl (1.576 mL, 20.49 mmol) and the reaction mass was stirred at RT for 16 h. The reaction was extracted with DCM (3×10 mL) and the organic layer was washed with water and a 10% aq. solution of NaHCO3, and then dried over Na2SO4, filtered and concentrated to afford Intermediate 302C as a pale yellow liquid (0.3 g, 62%). 1H NMR (400 MHz, chloroform-d) δ ppm 5.12 (s, 1H), 4.67-4.87 (m, 2H), 3.44-3.64 (m, 2H), 3.12-3.31 (m, 2H), 1.29 (d, J=6.53 Hz, 6H).

Provenance & Evidence