Sodium Hydroxide → 1773508-48-7

Participants

Reaction Steps

To a solution of Intermediate 302D (0.25 g, 1.189 mmol) in ethanol (5 mL) was added NaOH (1.189 mL, 5.95 mmol, 5 M in water) and the reaction mixture was stirred at RT for 8 h. The reaction mixture was concentrated in vacuo, dissolved in water and extracted with diethyl ether. The pH of the aq. solution was adjusted to 7 using a 2N aq. solution of HCl and extracted with DCM (3×10 mL) The combined organic layer was dried over Na2SO4, filtered, and the filtrate concentrated to afford Intermediate 302E as a pale yellow liquid (0.12 g, 60%). 1H NMR (400 MHz, DMSO-d6) δ ppm 13.02-13.40 (br. s., 1H), 4.53-4.76 (m, 2H), 2.95 (q, J=13.22 Hz, 2H), 2.59-2.78 (m, 2H).

Provenance & Evidence