Hydrochloric Acid → HCID 118062498, compound

Participants

Reaction Steps

To a stirred solution of Intermediate 352G (0.2 g, 0.458 mmol) in dioxane (1 mL) was added a solution of HCl in dioxane (2 mL, 8.0 mmol, 4 M). After stirring at RT for 2 h, the reaction mixture was concentrated and the crude product was triturated with hexanes to afford Intermediate 352H (0.17 g, 71%) as an off-white solid. MS(ES): −m/z=337 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.90 (ddd, J=1.8, 7.5, 14.3 Hz, 1H), 7.80-7.68 (m, 2H), 7.54-7.47 (m, 1H), 7.38 (dd, J=8.3, 9.8 Hz, 1H), 5.10 (br. s., 1H), 4.63 (br. s., 1H), 4.56 (s, 2H), 4.20-3.98 (m, 4H), 3.57 (s, 1H).

Provenance & Evidence