HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 920901Generated: October 30, 2026
Iodoethane → Ethyl 2-isonicotinoylthiophene-3-carboxylate
https://huagongshe.com/reaction/920901
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Isonicotinoylthiophene-3-carboxylic acid | HCID 86683116 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 2-isonicotinoylthiophene-3-carboxylate | HCID 86683117 | 85.5% |
Reaction Steps
To a solution of 2-isonicotinoylthiophene-3-carboxylic acid (2.2 g, 9.4 mmol) from example 2.1 and Cs2CO3 (6.2 g, 18.9 mmol) in CH3CN (500 mL) was added CH3CH2I (2.9 g, 18.9 mmol) dropwise. The mixture was stirred at 30° C. for 48 h. The mixture was filtered and concentrated to give the title compound as yellow oil (2.1 g, 85.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273068B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-12aaae79a88842b49121054ed5447ce6 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
